EC Dental Science

Verruciform xanthoma is an uncommon lesion of the oral mucosa having unknown etiology. It accounts for 0.025 - 0.05% of all pathology cases. The age of occurrence varies widely from 2 to 89 years. But most oral cases occur in middle-aged persons with mean age of 40 - 50 years, and no gender predilection is apparent. Apart from the oral mucosa it affects the genital mucosa as well and is considered to be a reactive process rather than a true neoplasm. The lesion commonly has a verruciform appearance, but it may appear polypoid, papillomatous or sessile.

This is a case report of a 58-year-old male patient who was initially diagnosed as speckled leukoplakia with left buccal mucosa but upon histopathological analysis was diagnosed as verruciform xanthoma.

Keywords: Verruciform Xanthoma; Oral Histiocytosis Y; Verruciform Xanthoma with Buccal Mucosa

1. Shetty Akshay., et al. “Oral Verruciform Xanthoma: A Case Report and Literature Review”. Case Reports in Dentistry (2013): 1-4.
2. Shafer William G. “Verruciform Xanthoma”. Oral Surgery, Oral Medicine, Oral Pathology6 (1971): 784-789.
3. Harris L., et al. “Oral Verruciform Xanthoma”. Case Report1 (2015): bcr2014209216-bcr2014209216.
4. Sah Kunal., et al. “Verruciform Xanthoma: Report of Two Cases and Review on Pathogenesis”. Journal of Oral and Maxillofacial Pathology1 (2008): 41.
5. Monteiro Maria Carolina de Lima Jacy., et al. “Verruciform Xanthoma: Case Report”. RGO - Revista Gaúcha de Odontologia1 (2016): 79-82.
6. Mostafa Khaled A., et al. “Verruciform Xanthoma of the Oral Mucosa: A Clinicopathological Study with Immunohistochemical Findings Relating to Pathogenesis”. Virchows Archiv a Pathological Anatomy and Histopathology4 (1993): 243-248.
7. Connolly SKYB., et al. “Management of Cutaneous Verruciform Xanthoma”. Journal of the American Academy of Dermatology2 (2000): 343-347.
8. Oliveira P. “Verruciform Xanthoma of the Oral Mucosa. Report of Four Cases and a Review of the Literature”. Oral Oncology3 (2001): 326-331.
9. Zegarelli David J., et al. “Verruciform Xanthoma”. Oral Surgery, Oral Medicine, Oral Pathology2 (1975): 246-256.
10. Shahrabi Farahani Shokoufeh., et al. “Oral Verruciform Xanthoma Associated with Chronic Graft-Versus- Host Disease: A Report of Five Cases and a Review of the Literature”. Head and Neck Pathology2 (2011): 193-198.
11. Neville Brad W and Et Al. Oral and Maxillofacial Pathology. St. Louis, Elsevier, Cop (2016).
12. Philipsen HP., et al. “Verruciform Xanthoma-Biological Profile of 282 Oral Lesions Based on a Literature Survey with Nine New Cases from Japan”. Oral Oncology4 (2003): 325-336.
13. Buchner A. “Verruciform Xanthoma of the Oral Mucosa. Report of Five Cases and Review of the Literature”. Archives of Dermatology9 (1981): 563-565.
14. Nowparast Bahram., et al. “Verruciform Xanthoma”. Oral Surgery, Oral Medicine, Oral Pathology6 (1981): 619-625.
15. Takehana S., et al. “Verruciform Xanthoma of the Gingiva: Report of Three Cases”. Journal of Oral and Maxillofacial Surgery10 (1989): 1079-1081.
16. Graff Steven G., et al. “Verruciform Xanthoma”. Oral Surgery, Oral Medicine, Oral Pathology5 (1978): 762-767.
17. Iamaroon Anak and Robert A Vickers. “Characterization of Verruciform Xanthoma by in Situ Hybridization and Immunohistochemistry”. Journal of Oral Pathology and Medicine7 (1996): 395-400.
18. Platkajs MA. “Verruciform Xanthoma of the Oral Mucosa. Report of Seven Cases and Review of the Literature”. Journal of the Canadian Dental Association5 (): 7018646.
19. Yu Chuan-Hang., et al. “Oral Verruciform Xanthoma: A Clinicopathologic Study of 15 Cases”. Journal of the Formosan Medical Association2 (2007): 141-147.
20. Yash C Manavadaria., et al. “Clinical Diagnostic Dilemma: Oral Verruciform Xanthoma”. Journal of Oral Medicine, Oral Surgery, Oral Pathology and Oral Radiology4 (2022): 243-246.