EC Cardiology

Research Article Volume 10 Issue 3 - 2023

Neutrophil-Lymphocyte Ratio and Coronary Artery Disease Risk in Patients Undergoing Coronary Angiography

Henrique Cotchi Simbo Muela1,2*, Fernando Muhongo Sandala1, José António Júlio Tito2, José Roberto Vilarinho dos Santos2, Guilherme Mendes Lima Franco1, António Gerson Bastos Francisco1, Isaura da Conceição Almeida Lopes1, Amílcar Bernardo Tomé da Silva1 and Pedro Magalhães1

1Department of Physiology, Faculty of Medicine, Agostinho Neto University, Luanda, Angola

2Cardiology Service, Sagrada Esperança Clinic, Luanda, Angola

*Corresponding Author: Henrique Cotchi Simbo Muela, Department of Physiology, Faculty of Medicine, Agostinho Neto University (Américo Boa Vida Hospital Backyard) Luanda, Angola.
Received: January 23, 2023; Published: February 00, 2023

Introduction: Inflammatory response is one of the main mechanisms in the pathogenesis of atherosclerosis and its progression. The neutrophil-lymphocyte ratio (NLR) has been proposed as an inflammatory biomarker and potential risk and prognosis predictor in cardiovascular disease (CVD).

Objective: To evaluate the association between the NLR and the severity of coronary artery disease (CAD).

Methods: An observational and retrospective study was carried out, including 56 patients aged ≥ 18 years (41 men and 15 women) who underwent diagnostic and/or therapeutic coronary angiography from 2014 to 2019 at Sagrada Esperança Clinic, Luanda, Angola. Demographic data, risk factors and comorbidities, biochemical tests and full blood count were collected from the patients’ medical reports. The NLR was calculated as the ratio between the total neutrophil and lymphocyte counts from the patients‘ full blood count. For the statistical analysis purposes, the sample was divided into two groups according to the median of NLR (median: 2.02): patients with NLR ≤median and patients with NLR> median. The statistical significance was set at 5%.

Results: The group of patients with CAD was relatively older than the group without CAD, although without any significant difference (58.49 ± 8.76 vs. 54.74 ± 8.7, p = 0.137). Likewise, the age was similar between groups considering the level of NLR (57.89 ± 8.60 vs. 56.54 ± 9.12, p = 0.571). The risk of having CAD and it being obstructive was twice as high in the group with NLR above the median (NLR > 2.02) compared to the group with a lower NLR (OR: 2.25, CI: 0.722 - 1.012 and 2.17, CI: 0.717 - 6.550, respectively). However, in general, our data suggested that there was no association between the neutrophil-lymphocyte ratio and the presence of CAD, nor with its severity (Χ2 = 1.991, p = 0.259 and Χ2 = 0.760, p = 0.562, respectively).

Conclusion: The risk of CAD occurrence, as well as the occurrence of obstructive CAD was twice higher in the group with higher neutrophil-lymphocyte ratio.


Keywords: Cardiovascular Diseases; Inflammation; Neutrophil-Lymphocyte Ratio; Biomarkers; Atherosclerosis; Coronary Artery Disease

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Henrique Cotchi Simbo Muela., et al. “Neutrophil-Lymphocyte Ratio and Coronary Artery Disease Risk in Patients Undergoing Coronary Angiography”. EC Cardiology  10.3 (2023): 19-27.