EC Clinical and Medical Case Reports

Case Report Volume 6 Issue 5 - 2023

Break-Through Invasive Pulmonary Aspergillus Infection in a Lung Transplant Recipient

Adil Sheikh1* and Michael Duncan2

1Lung Transplant and Adult ECMO Program, Division of Pulmonary, Critical Care, Sleep and Occupational Medicine, Department of Medicine, Indiana University School of Medicine, United States

2Division Chief Pulmonary and Critical Care Medicine Baylor University Medical, Center-Dallas Baylor Scott and White Health, United States

*Corresponding Author: Adil Sheikh, Assistant Professor of Clinical Medicine, Pulmonary and Critical Care, Department of Medicine, Indiana University School of Medicine, United States.
Received: April 20, 2023; Published: May 01, 2023

Current available evidence is equivocal on the effectiveness of anti-fungal prophylaxis against development of invasive fungal infections in lung transplant recipients. We present the case of a lung transplant recipient with breakthrough invasive pulmonary Aspergillus infection despite being on targeted anti-fungal prophylaxis with isavuconazole in the setting of augmentation of immunosuppression for acute cellular rejection. Breakthrough invasive fungal infections are important to recognize as they are associated with significant morbidity and mortality risk. To our knowledge, our case is among the handful reports of breakthrough invasive Aspergillus infection in the lung transplant population while on isavuconazole, antifungal prophylaxis.

Keywords: Case Report; Lung Transplant; Pulmonary Aspergillosis; Breakthrough Invasive Fungal Infections (b-IFI); Isavuconazole

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Adil Sheikh and Michael Duncan. "Break-Through Invasive Pulmonary Aspergillus Infection in a Lung Transplant Recipient." EC Clinical and Medical Case Reports   6.5 (2023): 53-57.